Hemp Based Cannabinoids
Delta 8 THC
Delta 8 THC is a naturally occurring cannabinoid formed when Delta-9 THC oxidizes into cannabinol (CBN). It is a transitionary cannabinoid that is found in small quantities. New research may implicate Delta-8THC and CBN in the “couch lock” sensation reported by some cannabis users. Delta 8 THC and Delta 9 THC are naturally occurring psychoactive cannabinoids found in the cannabis plant. Both create perceptible effects in users once consumed. Users may experience a rapid onset of effect when using a vaporizer or using smokable hemp flower. Users of edibles may experience a delayed onset of effects for up to four hours. Though similar, the most significant difference between Delta 8 THC and Delta 9 THC is the molecular structure, with the main difference being the location of the double bond on the carbon chain. Delta 8 has a double bond on the eighth carbon chain, whereas Delta 9 has a double bond on the ninth carbon chain. This difference affects the receptors to which the THC cannabinoids bind. Delta 8 THC is more likely to bond with CB2 receptors, unlike Delta 9 THC, which has a strong affinity for CB1 receptors. The Agricultural Improvement Act of 2018, also known as the 2018 Farm Bill, defines hemp as Cannabis Sativa with a Delta 9 THC maximum concentration of 0.3% on a dry weight basis. This definition was upheld on June 10, 2022, by the United States Court of Appeals for the District of Columbia Circuit. Delta 8 THC and Delta 9 THC products are produced from hemp extracts, thus making them legal for sale in many states. This should be considered an experimental product as there is no long-term research or definitive research surrounding the potential benefits or harms of using products containing Delta 8 THC. While Delta 8 THC and Delta 9 THC products are potency and safety tested by independent third-party laboratories, they are produced without regulatory oversight for efficacy or safety. The National Cancer Society defines Delta 8 THC as; "An analogue of tetrahydrocannabinol (THC) with antiemetic, anxiolytic, appetite-stimulating, analgesic, and neuroprotective properties. Delta-8-tetrahydrocannabinol (delta-8-THC) binds to the cannabinoid G-protein coupled receptor CB1, located in the central nervous system; CB1 receptor activation inhibits adenyl cyclase, increases mitogen-activated protein kinase activities, modulates several potassium channel conductances and inhibits N- and P/Q-type Ca2+ channels. This agent exhibits a lower psychotropic potency than delta-9-tetrahydrocannabinol (delta-9-THC), the primary form of THC found in cannabis."
Delta 9 THC
Delta-9-tetrahydrocannabinol (Delta 9 THC) is an intoxicating and psychoactive cannabinoid found in cannabis. It is the most well-known cannabinoid in the plant, responsible for the cannabis “high. It can induce a variety of sensory and psychological effects, including mild reverie, euphoria, increased sensory awareness, and some therapeutic benefits.
CBD & other Unique minor cannabinoids
Cannabidiol (CBD), derived directly from hemp, is the second most prevalent cannabinoid in cannabis. CBD is psychoactive but non-intoxicating. Commonly used to address stress, anxiety, and insomnia. Limited studies suggest it may reduce the perception of neuropathic and inflammatory pain.
Delta-10-tetrahydrocannabinol (Delta 10 THC) is a rare molecular relative of Delta-8 and Delta-9 THC. It is reported to promote greater creativity, euphoria, alertness, and energy. It is uplifting and perfect for daytime use. While very little research has been done on its mechanism of action in the body, it likely interacts with the endocannabinoid system in a similar way as other THC compound.
Tetrahydrocannabivarin (THCV), is a compound in cannabis that offers a unique array of effects and medical benefits. Research shows it is an appetite suppressant, may help with diabetes, may help reduce panic attacks, may help with Alzheimer’s and may help stimulates bone growth.
Tetrahydrocannabinol- O-Acetate (THC OA) is a cannabinoid like THC, CBD, CBG, and CBN. Many describe the effects of THC-O as very spiritual and introspective. Very cerebral, can produce anxiety in some.
Cannabinol (CBN) is a non-intoxicating compound that forms when cannabis ages and may create a sedative effect. Studies on CBN have found that it may have antibacterial properties, act as a neuroprotectant, appetite stimulant. Preclinical and animal studies have shown it to help with glaucoma and rheumatoid arthritis.
Cannabichromene (CBC) CBC is non-intoxicating, so it doesn't produce a euphoric high like THC. Animal studies that it may help block pain associated with collagen-induced osteoarthritis. Preclinical studies suggest it may be an effective antidepressant when using in combination with both THC and CBD.
Cannabigerol (CBG) Is considered a proto-molecule or the mother cannabinoid because all cannabinoids are derived from Cannabigerol acid (CBGA), the acidic form of CBG. It is non-psychotropic, and preclinical studies indicate it may be a promising analgesic, therapy for psoriasis, and an antidepressant. It is also thought to be particularly effective in treating glaucoma.